Metabolic rates were determined by normalizing absolute changes in metabolite abundances to protein content as previously described 20. The bioprofile phox is the first analyzer of its type designed to specifically measure the acidbase and respiratory parameters from cell culture and fermentation. Opc certification is the process of ensuring that applications meet the standards specified by the opc foundation. Specify folders that you want software analyzer to exclude from scanning. To measure the rates of metabolite consumptionsecretion in the medium, glucose, lactate, glutamine, and glutamate were measured using a bioprofile basic 4 analyzer nova biomedical, waltham, ma.
Automated cell culture analyzer with maint 2 bioprofile flex2 combines novas groundbreaking microsensor cardtm technology with optical measurement and freezing point osmometry for an automated and comprehensive. Matrix the turnkey multi bioreactor platform that adapts. Bioprofile phox is the first analyzer designed specifically to provide rapid, accurate measurement of acid base and respiratory parameters in cell culture and. Nova offers 4 models of bioprofile analyzers with test menus. Bioprofile phox is designed to measure acidbase and respiratory parameters from mammalian cell culture and bacterial fermentations. You enjoy investigating every nook and cranny of information, and can absorb information like a sponge does water. Nova biomedical bioprofile phox chemistry analyzer model.
Isotopic labeling was performed in dmem with 10% dialyzed fbs supplemented with either 10 mm duc. The nova bioprofile flex analyzer opc server is opc certified. Opc certification means multivendor system interoperability is guaranteed. Opc certification requires extensive testing to ensure true interoperability.
Nova bioprofile analyzers include four models of fully automated cell culture analyzers with test menus of two to ten tests, including chemistry, gases, and electrolytes. Bioprofile analyzers are fully automated and are designed for easy use by the operator. A complete 40sample tray can be analyzed in approximately 80 minutes. Each model offers automatic calibration, onebutton operation, and 40 position batch processing capability.
The modular design of bioprofile flex can be customized with one to four analytical modules to consolidate up to 15 vital cell culture tests. Further, bioprofile basic 2 is easily fieldupgradeable to the bioprofile basic 4. Saves as much as 30 minutes per sample compared to using multiple instruments. Bioprofile flex2 combines novas groundbreaking microsensor card technology with optical measurement and freezing point osmometry for an automated. Alanine and aspartate concentrations in media were quantitated using gcms by spiking a known concentration. Bioprofile chemistry analyzers, cell culture chemistry analyzers. Nova biomedical stat profile phoxbasic pluslc thermal. Automated cell culture analyzer with maintenancefree bioprofile flex2 combines novas groundbreaking microsensor card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume. Nova biomedical bioprofile flex automated cell culture. The bioprofile phox provides rapid, accurate measurement of ph, po2, and pco2 in the most appropriate ranges for cell culture and fermentation process development. Rapid communication open access metabolic changes in. The userfriendly software is fully compliant with 21 cfr part 11. By design, the bioprofile flex was constructed to facilitate the sharing of data between other devices.
Bioprofile flex modular cell culture analyzer by nova. Bioprofile flex analyzer one automated analyzer for fast. Culture media was collected at the end of the incubation and analyzed for glucose, lactate, glutamine, and glutamate content using an automated electrochemical analyzer nova bioprofile basic 4 analyzer. All bioprofile flex software is fully compliant with fda 21 cfr part 11. Included in your purchase price is all software updates, 247 access to. Up to 16 key assays can be simultaneously analyzed from a. Up to 16 cell culture tests in one analyzer 11 chemistry. Analysis of hypoxiainduced metabolic reprogramming. Random access analyzer clinical chemistry dedicated reagents throughput of 150 testhour 4 independent positions for samples and reagent racks 24 samples for rack maximum capacity of 72 samples in racks 10 reagents for rack maximum capacity of 30 reagent bottles in racks 20 and 50 ml reagent bottles primary tubes or paediatric cups as sample containers unlimited stat. Automated analyzer for fast comprehensive cell culture. Bioprofile basic 4, glutamine, glutamate, glucose, lactate. Test menu choices include glucose, lactate, glutamine, glutamate, ph, po 2, pco 2, ammonium, sodium, potassium, ionized calcium, cell density, cell viability, cell diameter, osmolality, and igg or phosphate. Bioprofile automated chemistry analyzers syntech innovation.
The bioanalyzer is a chipbased capillary electrophoresis machine to analyse rna, dna, and protein. Automated analyzer for fast comprehensive cell culture analysis. Novas opc server software allows bioprofile to transfer analytical data on key chemistries to any bioreactor. Bioprofile basic, 100, 300, 400, phox nova bioprofile analyzers include four models of fully automated cell culture analyzers with test menus of two to ten tests, including chemistry, gases, and electrolytes. Nova biomedical stat profile host software disk version v2. Individual via syringecup automated batch using 20position sampling tray.
This instrument analyzes glucose, lactate, glutamine, and glutamate from medium aliquots of 0. To add a new folder, type its location into the text box or click browse, tick the relevant folder, and click ok to add another location to the list, click add. One automated analyzer for fast, comprehensive cell culture analysis bioprofile is a chemistrycell viability modular instrument that measures up to 15 key cell culture attributes. Not only do these units turn on and pass all tests, but they come to a. Based on the widely recognized and accepted trypan blue exclusion method, bioprofile cdv combines advanced technology in. Biolab nova bioprofile 400 automated biochemistry analyser. Bioprofile cdv bioprofile cdv incorporates advanced, stateoftheart technology for rapid, accurate measurement of cell density and cell viability in cell cultures. This compact, easy to use analyzer provides rapid, accurate results throughout a wide range of ph, pco2, and po2 levels encountered in cell cultures and fermentations. An economical, automated chemistry analyzer from nova biomedical provides. This combination allowed the manufacturer to create a range of simpletouse analyzer that its characteristics meet the. Bioprofile flex2 combines novas groundbreaking microsensor card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume. The analyzers series stat profile phox combines the proven classic sensor system and a relatively new good solution for linking reagents in the form of cartridges. To remove a location, click the relevant row, then click delete note. Proprietary software the compact bioprofile flex footprint saves up to 1520 square feet of valuable bench space and saves hours of aintenance each month andm identify viable unstained and nonviable stained cells using compared to multiple instruments.
Bioprofile phox phgas analyzer pharmaceutical online. You must call to schedule a pickup before arriving. Download microsoft software inventory analyzer documents. Metabolic changes in cancer cells upon suppression of myc. The sale of this item may be subject to regulation by the u. Bioprofile basic offers all of the advanced features. Bioprofile flex 2 cell culture analyzer tecom analytical systems. Bioprofile automated chemistry analyzers for cell culture and. Metabolic plasticity maintains proliferation in pyruvate. Nova biomedical bioprofile flex automated, modular, multitest cell culture analyzer in good condition with 90day warranty whether youre looking for another analyzer to replace your bioprofile flex instrument, a backup instrument, or just a unit for parts, this bioprofile flex analyzer will suit your needs. Glucose, lactate, glutamine and glutamate concentrations were measured in fresh and spent culture medium using a bioprofile basic 4 analyzer nova. Using ramanrxn2 for the analysis of a mammalian cell culture. You are caring and unselfish, and like to bring your intelligent and humane perspective to all. Bioprofile chemistry analyzers for mammalian cell culture.
Glucose and lactate can be measured using automated analyzers or various enzymatic assays, many of which exist as commercial kits. Exceptions that you specify on this screen only apply to software analyzer and do not. Nova biomedical bioprofile flex automated cell culture chemistry analyzer. Automatic measurement bioprofile provides faster and more accurate results than the offline methods. Bioprofile phox is designed to specifically measure the acidbase. Bioprofile data manager software available but not included. A new, automated modular analyzer from nova biomedical provides fast. The bioprofile basic 2 automated chemistry analyzer is intended to replace competitive glucoselactate analyzers with stateoftheart technology and consistent, reliable glucose and lactate measurement. Bioprofile flex is a chemistrycell viability modular instrument that measures up to. The combination of reduced sample volume, fast analysis time and maintenancefree makes bioprofile flex2 the first choice in regard to sample analysis from minimicrobioreactor systems the full 16 cell culture test menu includes glucose, lactate, glutamine, glutamate, ammonium, sodium, potassium, ionized calcium, ph, pco2, po2, total cell density, viable cell density.
Automated modular analyzer provides fast, comprehensive cell. Robust software for determination of cell specific. Statprofile prime the new definition of simplicity for cell culture monitoring introducing a new generation cell culture analyzer that combines the revolutionary microelectronics of the consumer world with nova biomedicals innovative microsensor card technology for a. Novas opc server software allows bioprofile to transfer analytical data on key chemistries to. Nova biomedical 400 36664 bioprofile analyser t08806160. Bioprofile flex2 automated cell culture analyzer from nova. Opc server for nova biomedical flex analyzer user manual. Aspartate and alanine were measured using highpressure liquid chromatography hitachi l8900. The results obtained by analyzer bioprofile, show excellent correlation with the conventional measuring methods. Software designed to track inventories, manage schedules, aggregate data, provide resource visibility, and integrate with other lab systems compliance services services including instrumentsoftware qualifications, consulting and custom validations focused on data integrity.
An economical, automated chemistry analyzer from nova biomedical provides rapid, accurate measurement of glucose and lactate in cell culture and fermentation media. Opc connectivity to the nova biomedical bioprofile flex analyzer makes it possible to. This unique system combines multiple levels of controls and dedicated software. By combining as many as five separate instruments into one easytouse instrument, bioprofile flex simplifies workflow and saves time, labor, and operating cost. Includes manual, printer, and 40 position sample tray. We have had success with an automated electrochemical analyzer bioprofile basic 4 analyzer, nova.
According to the company, the bioprofile basic 2 automated chemistry analyzer is intended to replace competitive glucoselactate analyzers with stateoftheart technology and consistent, reliable glucose and lactate measurement. Novas opc server software allows total system management. Bioprofile flex analyser, bioprofile flex analyser. Cell culture analyzer bioprofile phox nova biomedical ph. It is produced by agilent and widely used, among other things, in rna quality control measurements before downstream experiments like microarrays. Nova biomedical 400 bioprofile analyser nova bioprofile analyzers include four models of fully automated cell culture analyzers with test menus of two to ten tests, including chemistry, gases, and electrolytes.